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KMID : 0380219930260040308
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Journal of Biochemistry and Molecular Biology
1993 Volume.26 No. 4 p.308 ~ p.311
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Activations of p34 and pp60 Kinases in Regenerating Rat Liver
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Seon-Yang Park
Jeong Ahn and Jong Sang Park
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Abstract
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We examined the involvement of p34cdc2 (maturation promoting factor catalytic subunit) and pp60c-src protein tyrosine kinases in regenerating rat liver. Maximum DNA synthesis reaches at 24 h after partial hepatectomy (PH) and 6 h later cell division starts (30 h after PH) [Bae, S. C. (1991) Ph. D. Dissertation, Seoul National University, 6-10]. p34cdc2 was activated at 24 and 30.5 h after PH. These activations corresponded to the period of DNA synthesis and mitosis in regenerating rat liver. On the other hand, pp60c-src kinase was inactivated at first during preproliferation and S phase, however, reactivation occurred to the control level at 30.5 h after PH corresponding to the period of mitosis. These results suggest that both kinases are involved in the regeneration of rat liver.
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